A novel PCL/HA/TiO2 hybrid coating on ZM21 Mg alloy substrate has been investigated for corrosion resistance, biocompatibility and mechanical integrity loss in terms of bending, compressive and tensile strength in physiological media. The electrochemical measurement and in-vitro degradation study in SBF after 28 days showed that the PCL/HA/TiO2 hybrid coating reduced H2 evolution rate, weight loss, and corrosion rate by 64, 116 and 118 times respectively, as compared to uncoated ZM21 samples. The in-vitro cellular viability of L929 fibroblast cells on PCL/HA/TiO2 hybrid coating was found 50.47% higher with respect to control group, whereas bacterial viability was supressed by 57.15 and 62.35% against gram-positive Staphylococcus aureus and gram-negative Escherichia coli bacterial models. The comprehensive assessment indicates PCL/HA/TiO2 hybrid coating as a suitable candidate to delay early degradation and mechanical integrity loss of Mg-based alloys for devising biodegradable orthopaedic implant.
Dr. Uma Batra
|Collaborations||Wichita State University, United States|